The well intersected about 18.5 m of net gas pay within the Jurassic sandstone target reservoir.
Wireline logs have confirmed the discovery and gas samples have been brought to the surface.
Woodside has not quantified the find, but observers suggest a resource of several hundred billion cubic feet.
Pyxis offers future tie-back potential to the existing Pluto infrastructure, including the onshore One-train LNG plant on the Burrup Peninsula.
The well was drilled by the Transocean Ltd.-owned Deepwater Millennium ultradeepwater drillship.